Electric Literature of 6940-78-9, A common heterocyclic compound, 6940-78-9, name is 1-Bromo-4-chlorobutane, molecular formula is C4H8BrCl, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
7.16 g of 7-hydroxy-2-quinolinone, 51.5 g of 1-bromo 4-chlorobutane, 37.32 g of potassium carbonate and4.18g of ethoxyformylmethylenetriphenylphosphine dissolved in 170mL of acetone, reacted at 45 C for 2.5h,After the reaction, 100 ml of a saturated sodium chloride solution was added, followed by extraction with ethyl acetate.The ethyl acetate extract was washed successively with saturated sodium chloride solution and deionized water.Dry over anhydrous sodium sulfate, concentrate under reduced pressure and dried in vacuo.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Wuhan Xing Hua Knowledge Pharmaceutical Technology Co., Ltd.; Lu Shan; Chen Jingrun; Zhang Chuantao; (16 pag.)CN109988162; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics