Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2845-89-8, name is 1-Chloro-3-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C7H7ClO
NaOtBu (577mg, 6.0mmol) was added to a dry round-bottom flask and the solid stirred for 12h at 120C under Ar. 42 Diglyme (7 mL) was added and the resulting suspension was sequentially treated with 15 N-methylaniline (306mug, 3.0mmol), 14 3-chloroanisole (365mul, 3.0mmol) and a suspension of 40 Pd(OAc)2 (14mg, 0.06mmol) and ligand 36 4b (28mg, 0.06mmol) in diglyme (2 mL). After being stirred at 120C for 3 d, the reaction mixture was passed through a bed of silica gel and the residue was washed with MeOH. The filtrate was evaporated to dryness in vacuo to give 638mg (quant.) of compound 29 as a yellow solid, mp. 67C (MeOH). IR (neat): upsilon=3058, 3034, 2999, 2938, 2833, 2812, 1591, 1575, 1495, 1456, 1347, 1273, 1214, 1168, 1127, 1094, 1048, 990, 929, 847, 753, 691cm-1. 13C NMR (CDCl3, 400MHz): delta=40.40 (q, 1C), 55.26 (q, 1C), 105.70 (d, 1C), 106.00 (d, 1C), 112.62 (d, 1C), 121.70 (d, 2C), 121.96 (d, 1C), 128.44 (d, 2C), 129.08 (d, 1C), 148.98 (s, 1C), 150.49 (s, 1C), 160.66 (s, 1C). MS (EI+, 70eV): m/z=213 (100) [M+], 197 (5), 154 (5). HRMS (EI+, 70eV): m/z=C14H15NO calcd.213.1154; found 213.1155.
According to the analysis of related databases, 2845-89-8, the application of this compound in the production field has become more and more popular.
Reference:
Article; Wittel, Baerbel; Vogel, Till; Scharl, Heiko; Nerdinger, Sven; Lehnemann, Bernd; Meudt, Andreas; Snieckus, Victor; Bioorganic and Medicinal Chemistry; vol. 26; 15; (2018); p. 4583 – 4593;,
Chloride – Wikipedia,
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