Application of 110407-59-5, These common heterocyclic compound, 110407-59-5, name is 2-Chloro-4-fluorobromobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: NiCl2(PCy3)2 (17 mg, 0.025 mmol) was added to a substrate (0.5 mmol) in dry THF (4 mL – 10 mL) and then LiAl(O-t-Bu)3H (2 mmol – 8 mmol, ) was added to this solution slowly under argon atmosphere. The mixture was then heated to reflux and left to stir while being periodically monitored by GC and GC/MS. All products were identified by GC/MS and GC.
Statistics shows that 2-Chloro-4-fluorobromobenzene is playing an increasingly important role. we look forward to future research findings about 110407-59-5.
Reference:
Article; Xiao, Juan; Wu, Jingjing; Zhao, Wenwen; Cao, Song; Journal of Fluorine Chemistry; vol. 146; (2013); p. 76 – 79;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics