Reference of 870-24-6, A common heterocyclic compound, 870-24-6, name is 2-Chloroethanamine hydrochloride, molecular formula is C2H7Cl2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1. In a 500 ml four-necked flask equipped with magnetic stirring, 20.0 g of beta-mercaptoethanol and 1.0 g of Fe-EG catalyst were added, and 50 ml of a newly prepared 30% strength NaOH solution was added dropwise at room temperature.After 15 minutes of dropwise addition, the temperature was raised to 50 C, and 30.0 g of 2-chloroethylamine hydrochloride was dissolved in 17.3 ml of water.Slowly drip into the above reaction bottle, 1h drop addition, continue to keep warm at 50 C and stir for 0.5h;Step 2, after the reaction, the solution is light yellow transparent, a small amount of white solid precipitates at the bottom, the system pH=10, the upper clear liquid is dried at 50 C to obtain a beige viscous liquid, the product is dissolved with absolute ethanol, filtered, and the filtrate is decompressed. Distillation gave the pale yellow viscous liquid product 2-amino-2-hydroxy-diethyl sulfide.
The synthetic route of 870-24-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Fuzhou Huabolile New Materials Technology Co., Ltd.; Mei Dandan; Yang Guilian; (7 pag.)CN108373432; (2018); A;,
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