Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 50638-46-5, name is 4-Bromo-3-chloroanisole, A new synthetic method of this compound is introduced below., Recommanded Product: 4-Bromo-3-chloroanisole
Example 1 Preparation of diethyl 2-chloro-4-methoxyphenylmalonate At about 60 C., diethyl malonate (0.49 mol) was added, over a period of 2 hours, to a suspension of sodium hydride (0.51 mol) in 140 ml of 1,4-dioxane. After a further 10 min of stirring, 0.05 mol of CuBr was added. After 15 min, 0.25 mol of 1-bromo-2-chloro-4-methoxybenzene in 10 ml of dioxane was added. The reaction mixture was kept at 100 C. for about 14 hours, and 35 ml of 12N hydrochloric acid were then added slowly at about 15 C. The precipitate was filtered off and the filtrate was extracted with diethyl ether. After phase separation, the organic phase was dried and then freed from the solvent. 34 g of the title compound remained.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Tormo i Blasco, Jordi; Biettner, Carsten; Muller, Bernd; Gewehr, Markus; Grammenos, Wassilios; Grote, Thomas; Rheinheimer, Joachim; Schafer, Peter; Schieweck, Frank; Schwogler, Anja; Wagner, Oliver; Scherer, Maria; Strathmann, Siegfried; Schofl, Ulrich; Stierl, Reinhard; US2007/149400; (2007); A1;,
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