Related Products of 6276-54-6,Some common heterocyclic compound, 6276-54-6, name is 3-Chloropropan-1-amine hydrochloride, molecular formula is C3H9Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 3-chloropropylamine hydrochloride (5.0 g, 38.5 mmol) in water (15 mL) wasslowly added a solution of NaN3 (7.5 g, 115.3 mmol) in water (30 mL). The resulting solution washeated at 80 C for 18 h. After cooling to room temperature, about 1/2 to 2/3 of the water was removedunder vacuum. The remaining residue was diluted with ether (50 mL). This biphasic mixture wascooled in an ice bath for 5 min and KOH (2.0 g) was added. The phases were separated and theaqueous phase was extracted with diethyl ether (2 x 50 mL). The organic layers were combined, driedwith Na2SO4, and concentrated to give the 3-azidopropylamine as light yellow oil (2.9 g, 29.0 mmol)in 75% yield. 1H-NMR (CDCl3): delta3.39-3.36 (t, 2H), 2.82-2.79 (t, 2H), 1.77-1.70 (m, 2H), 1.45 (bs, 2H).ESI-MS: m/z calcd for C3H9N4: 100.1, found 101.1 [M + H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Chloropropan-1-amine hydrochloride, its application will become more common.
Reference:
Article; Guo, Zhide; Gao, Mengna; Song, Manli; Shi, Changrong; Zhang, Pu; Xu, Duo; You, Linyi; Zhuang, Rongqiang; Su, Xinhui; Liu, Ting; Du, Jin; Zhang, Xianzhong; Molecules; vol. 21; 6; (2016);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics