Adding a certain compound to certain chemical reactions, such as: 7006-52-2, name is N-Methyl-3-chloroaniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7006-52-2, name: N-Methyl-3-chloroaniline
To a 20 ml microwave tube was added 3-chloro-N-methylaniline (300 mg, 2.13 mmol), ethyl 2-bromoacetate (426 mg, 2.55 mmol).Diisopropylethylamine (550 mg, 4.26 mmol) and 10 ml of acetonitrile, the mixture was reacted under microwave at 100 ° C for 2 hours.The reaction was stopped, cooled to room temperature, concentrated, and the residue was applied to a column (yield: petroleum ether: ethyl acetate = 10:1) to give compoundN-(3-Chlorophenyl)-N-methylglycine ethyl ester (460 mg, yield 95percent).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, N-Methyl-3-chloroaniline, and friends who are interested can also refer to it.
Reference:
Patent; Shenzhen Weixin Biological Technology Co., Ltd.; Yu Jindi; Lu Xianping; Li Zhibin; Xin Lijun; Zhu Jiangfei; Fu Chao; (67 pag.)CN108203438; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics