Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 97329-43-6, name is 1-Bromo-2-chloro-3-methylbenzene, A new synthetic method of this compound is introduced below., Quality Control of 1-Bromo-2-chloro-3-methylbenzene
A mixture of 1-bromo-2-chloro-3-methylbenzene (4.0 g, 19.6 mmol), Pd2dba3 (1014 mg, 0.98 mmol), Xantphos (566 mg, 0.98 mmol), tert-butyl carbamate (3.41 g, 29.4 mmol) and Cs2CO3 (9.58 g, 29.4 mmol) in dioxane (120 mL) was stirred at 110 C. for 2 h and then cooled to rt. Water (150 mL) was added and the mixture was extracted by EtOAc (150 mL×2). The organic layer was dried and concentrated. The residue was purified by flash column chromatography (PE , 100%) to afford the title compound (4.2 g, 89%). MS (ES+)C12H16ClNO2 requires: 241, found: 187 [M-55+H]+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; JONES, Philip; CZAKO, Barbara; CARROLL, Christopher L.; MANDAL, Pijus; CROSS, Jason; (64 pag.)US2020/48249; (2020); A1;,
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