These common heterocyclic compound, 918538-05-3, name is 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine
General procedure: In a 50mL reaction vial, Pd(PPh3)2Cl2 (30mg, 0.042mmol) and NEt3 (121mg, 1.2mmol) were added to a solution of 12 (80mg, 0.424mmol) and 4-trifluoromethoxylphenylboronic acid (90mg, 0.44mmol) in DMF (28.5mL) and H2O (0.5mL). The mixture was stirred at 80C for 4h under N2 atmosphere. The reaction mixture was cooled to room temperature and filtrated. The filtrate was diluted with H2O (100mL) and then extracted with EtOAc, and the organic layer was dried over anhydrous Na2SO4, after filtration, the filtrate was evaporated and purified by chromatography (petroleum ether/EtOAc, 20:1) to give the product 13 as a yellow solid (97mg, 78%).
The synthetic route of 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine has been constantly updated, and we look forward to future research findings.
Reference:
Article; Xin, Minhang; Zhang, Liandi; Tang, Feng; Tu, Chongxing; Wen, Jun; Zhao, Xinge; Liu, Zhaoyu; Cheng, Lingfei; Shen, Han; Bioorganic and Medicinal Chemistry; vol. 22; 4; (2014); p. 1429 – 1440;,
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