Application of 7006-52-2,Some common heterocyclic compound, 7006-52-2, name is N-Methyl-3-chloroaniline, molecular formula is C7H8ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Chlorosulfonic acid (75 ml, 1130 mmol) was cooled to 0° C. and stirred during the slow addition of N-methyl-3-chloroaniline (10.0 g, 70.6 mmol). The reaction mixture was heated between 118-135° C. for 4.5 hours and allowed to stand at room temperature overnight. The mixture was slowly poured into a bath of ice water and the resulting semi-solid was extracted with hot chloroform (2.x.200 mL). The combined organic extractes were dried over MgSO4, and the solvent removed to near dryness under reduced pressure. The product was used in the next step without purification or analysis.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route N-Methyl-3-chloroaniline, its application will become more common.
Reference:
Patent; NitroMed, Inc.; US2006/189603; (2006); A1;,
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