Application of 766545-20-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 766545-20-4 as follows.
To a solution of 2-chloro-5,6,7,8-tetrahydro-l,6-naphthyridine hydrochloride (available from Activate Scientific) (3.0 g, 15 mmol) in DCM (50 mL) was added NEt3 (4.44 g, 6.1 mL, 44 mmol). After 15 min, methylchloroformate (2.1 g, 1.7 mL, 22 mL) was added and the resulting mixture stirred at RT for 16 h. The reaction was diluted with DCM, washed with saturated NaHCO3 (aq.), then brine, dried (MgSO4), filtered and concentrated in vacuo. The residue was purified by FCC (SiO2, eluting with 2:1 heptane / EtOAc) to give the title compound (3.17 g, 96%) as white solid.LCMS data: Calculated MH+ (227); Found 100% (MH+) m/z 227, Rt = 1.11 (2 min method). 1H NMR (500 MHz, CHLOROFORM-J) delta ppm 7.38 (1 H, br. s.), 7.18 (1 H, d, J=8.1 Hz), 4.62 (2 H, br. s.), 3.78 – 3.83 (2 H, m), 3.72 (3 H, s), 3.00 (2 H, t, J=5.3 Hz).
According to the analysis of related databases, 766545-20-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; EVOTEC NEUROSCIENCES GMBH; WO2009/121812; (2009); A1;,
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