Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 139512-70-2, name is 4-Chloro-5-fluorobenzene-1,2-diamine, A new synthetic method of this compound is introduced below., name: 4-Chloro-5-fluorobenzene-1,2-diamine
General procedure: To a solution of the desired carboxylic acids (17, 18, 19, 22 or 23)(1 mmol) in DMF (5 mL) at 0 C was added DIPEA (0.21 mL,1.2 mmol). TBTU (385 mg, 1.2 mmol) was added and the resultingmixture were stirred at 0 C for 30 min. Then the desired diaminobenzenederivative (1.1 mmol) was added. The mixture wasstirred at room temperature for 6 h and then quenched with icewater.The precipitated solid was filtered, washed with water, anddissolved in EtOAc. The organic layer was washed with a 1 N HClaqueous solution, then with a saturated NaHCO3 aqueous solutionand finally H2O, dried over MgSO4, and concentrated in vacuo,whichwas used in the next step without further purification. To theappropriate amide was added AcOH (10 mL), and the mixture wasrefluxed overnight, cooled to room temperature and concentratedunder reduced pressure. The residue was purified by flashchromatography.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Fang, Yuying; Zhou, Huihao; Gu, Qiong; Xu, Jun; European Journal of Medicinal Chemistry; vol. 167; (2019); p. 133 – 145;,
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