Reference of 6579-54-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6579-54-0 as follows.
General procedure: To a stirred solution of 4 (1.0 mmol) in THF (5 mL) was added appropriate sulfonyl chloride (1.1 mmol) and NaHCO3 (38 mmol). The reaction mixture was stirred at room temperature for 4 h under nitrogen atmosphere. Then the solvent was evaporated in vacuum. The residue was diluted with water. The whole mixture was extracted with AcOEt for three times. The combined organic layer was washed with water, sat. brine, and dried over Na2SO4. The crude product was purified by column chromatography using petroleum ether/AcOEt (10/1-8/1, v/v) as eluent to afford F01-F35.
According to the analysis of related databases, 6579-54-0, the application of this compound in the production field has become more and more popular.
Reference:
Article; Zhang, Wen-Ming; Yao, Yang; Yang, Teng; Wang, Xue-Ying; Zhu, Zhen-Yun; Xu, Wen-Tao; Lin, Hai-Xia; Gao, Zhao-Bing; Zhou, Hu; Yang, Cai-Guang; Cui, Yong-Mei; Bioorganic and Medicinal Chemistry Letters; vol. 28; 10; (2018); p. 1943 – 1948;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics