Reference of 202197-26-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 202197-26-0 as follows.
Compound 12 (1.6 g, 6.28 mmol), commercially available 3-chloro-4-(3-fluorobenzyloxy)aniline 13 (1.6 g, 6.3 mmol) and CH3SO3H (20 muL, 5 mol %) were added into anhydrous EtOH (40 mL) and the reaction mixture was heated at 70 C for 2 h. After cooled down, the alcohol solution was diluted with water (150 mL) and the resulting solid was filtered, washed with water and dried to give N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-5-iodo-6-methylpyrimidin-4-amine 14 (2.77 g, 94%) as a white solid. MS-ESI (m/z): 467.8(M-H), 470.0(M+H); 1H NMR (CDCl3, delta): 2.65(s, 3H), 5.15(s, 2H), 6.94(d, 1H), 7.02(t, 1H), 7.16(d, 1H), 7.22(d, 1H), 7.35(d, 2H), 7.67(s, 1H), 8.39(s, 1H).
According to the analysis of related databases, 202197-26-0, the application of this compound in the production field has become more and more popular.
Reference:
Article; Mao, Yongjun; Zhu, Wenxiu; Kong, Xiaoguang; Wang, Zhen; Xie, Hua; Ding, Jian; Terrett, Nicholas Kenneth; Shen, Jingkang; Bioorganic and Medicinal Chemistry; vol. 21; 11; (2013); p. 3090 – 3104;,
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