Electric Literature of 6579-54-0, These common heterocyclic compound, 6579-54-0, name is 2,6-Dichlorobenzenesulfonyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Under the condition of ice bath, 4-aminophenol hydrochloride 2 (1.46 g, 10 mmol) was dissolved in pyridine (50 mL). After 2-Naphthalenesulfonyl chloride (2.72 g, 12 mmol) was added drop by drop, the mixture was stirred at room temperature for 5 h (detected by TLC). Solvents were evaporated with the residues being taken up in EtOAc (50 mL). Then the organic layer was washed with saturated 1 N HCl (20 mL * 2), distilled water (20 mL * 2), brine (20 mL * 2), dried over anhydrous MgSO4 and evaporated under vacuum. The residues were purified by EtOH/H2O to give desired intermediate 3a.
The synthetic route of 6579-54-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Xu, Fuming; Zhang, Lei; Jia, Yuping; Wang, Xuejian; Li, Xiaoguang; Wen, Qingli; Zhang, Yingjie; Xu, Wenfang; European Journal of Medicinal Chemistry; vol. 69; (2013); p. 191 – 200;,
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