20850-43-5, name is 5-(Chloromethyl)benzo[d][1,3]dioxole, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C8H7ClO2
General procedure: Suspension of the appropriate 3-amino-1,1-dioxo-1,4,2-benzodithiazine derivative 4a-h (0.5 mmol), anhydrous K2CO3 (1.5 mmol, 0.21 g) and the appropriate alkyl chloride (0.6 mmol) in dry THF (5 ml) was heated at reflux for 20-24 h, then cooled in ice-bath and filtered off. The crude product was suspended in 5 ml of water, heated gently to ca. 50 C; and cooled with vigorous stirring until granular precipitate appeared. Filtering off and washing with cold water and diluted EtOH gave pure potassium salts. 4.5.7 ;N-{2-[(1,3-Benzodioxol-5-yl)methylthio]-4-chloro-5-(5-phenyl-1,3,4-thiadiazol-2-yl)benzenesulfonyl}cyanamide potassium salt (5k) ;Starting from 4c (0.204 g) and 1,3-benzodioxol-5-ylmethyl chloride (0.102 g). Yield: 0.287 g (99%): m.p. 285-287 C; IR (KBr): nu 3443, 2924, 2853, 2179, 1652, 1623, 1577, 1501, 1489, 1357, 1129 cm-1; 1H NMR (500 MHz, DMSO-d6): delta 4.35 (s, 2H, SCH2), 6.01 (s, 2H, OCH2O), 6.89 (d, J = 7.81 Hz, 1H, Ar), 6.97 (d, J = 7.81 Hz, 1H, Ar), 7.05 (s, 1H, Ar), 7.58-7.60 (m, 3H, Ar), 7.68 (s, 1H, Ar), 8.07-8.08 (m, 2H, Ar), 8.69 (s, 1H, Ar); Anal. C23H14ClKN4O4S3 (C, H, N).
The synthetic route of 20850-43-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Brozewicz, Kamil; Slawinski, Jaroslaw; European Journal of Medicinal Chemistry; vol. 55; (2012); p. 384 – 394;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics