Reference of 823-57-4,Some common heterocyclic compound, 823-57-4, name is 2-Bromo-5-chloroaniline, molecular formula is C6H5BrClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(1H-indol-2-yl)boronic acid ((1H-indol-2-yl) boronic acid) (100 g, 0.621 mol) 2-Bromo-5-chloroaniline (2-bromo-5-chloroaniline) (115 g, 0.558 mol) Was dissolved in toluene (Toluene), EtOH, H2O 1000 mL: 200 mL: 200 mL , Pd (PPh3) 4 (35.8 g, 0.031 mol) and NaHCO3 (156.5 g, 1.863 mol) were added and stirred at 100 ° C for 3 hours. After completion of the reaction, MC and distilled water are added to the reaction solution to be extracted. After drying with anhydrous MgSO 4, the solvent was removed using a rotary evaporator to obtain Compound 1-1 (110 g, 74percent) in liquid form.
The synthetic route of 823-57-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; L Ti Material Co., Ltd.; Ji Hye-su; Oh Han-guk; Lee Yun-ji; Jeong Won-jang; Choi Jin-seok; Choi Dae-hyeok; (217 pag.)KR2019/33911; (2019); A;,
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