Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7149-75-9, name is 4-Chloro-3-methylaniline, A new synthetic method of this compound is introduced below., SDS of cas: 7149-75-9
General procedure: A mixture of 4-chloro-3-(trifluoromethyl)aniline or its derivatives and CDI in dry CH2Cl2 (5mL) was stirred for 1h at room temperature, then compound 6 (194mg, 0.69mmol) or its derivatives was added. The mixture was allowed to stir for an additional 1h to afford white precipitates. The solid was collected by filtration under vacuum, washed with water for three times and dried under vaccum to give compound 7a?7m and 7p?7r [13], but 7m and 7n was synthesis by a condensation reaction between benzoic acid and compound 6 promoted by EDCI. The yields of all compounds were between 65.7percent and 82.4percent. The general synthetic route is depicted in Scheme 1.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Wu, Zeng; Yan, Ming; Hu, Shi-He; Yu, Zhi-Cheng; Zhu, Yong; Cheng, Ya-Dong; Liu, Hai-Chun; Zhang, Yan-Min; Yao, Si-Hui; Tang, Wei-Fang; Lu, Tao; Chinese Chemical Letters; vol. 25; 2; (2014); p. 351 – 354;,
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