Reference of 61881-19-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 61881-19-4 as follows.
To a solution of 10 (1 .5 g, 1 .4 mmol) in DCM (10 ml) and 2,2,2-trifluoro-/V-phenylacetimidoyl chloride (3 equiv), Cs2C03 (1 equiv) was added at 0C, and the reaction stirred at rt for 3 h. The solid was filtered off and the solvent evaporated. The crude was purified by flash chromatography (8:2 tol:acetone) to afford 11 as a brown foam in 82% yield (1 .15 g). HR ESI- MS m/z C55H55F3N202i [M+Na]+ 1 159.3147; found 1 159.3065. (Ando et al. Carbohydrate Research 338 (2003) 503-514)
According to the analysis of related databases, 61881-19-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GSK VACCINES S.R.L.; ADAMO, Roberto; BERTI, Francesco; CARBONI, Filippo; MARGARIT Y ROS, Immaculada; (66 pag.)WO2017/175082; (2017); A1;,
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