Related Products of 63624-28-2, The chemical industry reduces the impact on the environment during synthesis 63624-28-2, name is 2,4-Dimethoxybenzene-1-sulfonyl chloride, I believe this compound will play a more active role in future production and life.
To a solution of tert-butyl 3-(4-aminonaphthalen-1-yl)benzoate (70 mg, 0.22 mmol) in dichloromethane (2 mL) were added pyridine (35 muL, 0.4 mmol) and 2,4-dimethoxy-benzenesulfonyl chloride (100 mg, 0.4 mmol). The reaction mixture was stirred at room temperature for 30 h. Afterwards the reaction mixture was diluted with dichloromethane (5 mL) and washed with hydrogen chloride (1 M aqueous solution), dried over magnesium sulfate, filtered and then concentrated in vacuo. The resulting residue was dissolved in dichloromethane (3 mL). Trifluoroacetate (0.3 mL, 4 mmol) was added and the reaction mixture was stirred at room temperature for 3 h. The solvent was removed in vacuo and the resulting residue was purified by high performance liquid chromatography (RP silica gel, cetonitrile/water/trifluoroacetic acid). Lyophilization of the product fractions provided 48 mg, 47% of the title compound as a white powder.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,4-Dimethoxybenzene-1-sulfonyl chloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SANOFI; The designation of the inventor has not yet been filed; (58 pag.)EP2998294; (2016); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics