Adding a certain compound to certain chemical reactions, such as: 766545-20-4, name is 2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 766545-20-4, Product Details of 766545-20-4
A solution of 90 mg of 2-chloro-5,6,7,8-tetrahydro-[1,6]naphthyridine hydrochloride (U.S. Pat. No. 6,169,093), 0.134 g of N-carbobenzyloxyglycine, 0.130 g of triethylamine, and 0.087 g of 1-hydroxy-7-azabenzotriazole in DMF (2.7 mL) at 0 C. was stirred as 0.123 g (0.640 mmol) of EDC was added. After two hrs., the reaction mixture was poured into 4% magnesium sulfate solution, and the resulting solution was extracted with EtOAc and then methylene chloride. The organic extracts were dried over sodium sulfate, filtered, and concentrated to give an oil that solidified upon standing. Trituration with MeOH and collection of the solids provided the desired amide intermediate.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Pfizer Inc.; US2004/192698; (2004); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics