Related Products of 4535-90-4,Some common heterocyclic compound, 4535-90-4, name is 2-Chloro-N-methylethanamine hydrochloride, molecular formula is C3H9Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A9. (3RS,3aRS)-8-Fluoro-3-phenyl-3a,4-dihydro-3H-chromeno[4,3-c]pyrazole-2-carboxylic acid (2-chloro-ethyl)-methyl-amide; To an ice cold solution of 636 mg (1.92 mmol) (3RS,3aRS)-8-Fluoro-3-phenyl-3a,4-dihydro-3H-chromeno[4,3-c]pyrazole-2-carbonyl chloride (compound A7) in 40 ml dichloromethane are added 389 mg (3.85 mmol) triethyl amine and after 30 min a solution of 250 mg (1.92 mmol) 2-methylaminoethylchloride hydrochloride in 7 ml methanol. The mixture is stirred for 1 h at room temperature. Additional dichloromethane and a diluted aqueous solution of hydrochloric acid are added. The organic layer is dried with magnesium sulfate. The solvents are removed at reduced pressure. The crude product is purified by column chromatography (silica gel, light petroleum/ethyl acetate 2:1). 515 mg of the title compound are obtained as a yellowish solid. (m/z (MH+)=388.1).
The synthetic route of 4535-90-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Vennemann, Matthias; Baer, Thomas; Maier, Thomas; Lindenmaier, Andreas; Braunger, Juergen; Boehm, Markus; Zimmermann, Astrid; Gekeler, Volker; US2010/104659; (2010); A1;,
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