Adding a certain compound to certain chemical reactions, such as: 2533-69-9, name is Methyl 2,2,2-trichloroacetimidate, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2533-69-9, Product Details of 2533-69-9
A solution of 5,6-difluorobenzene-1,2-diamine (1.76 g, 12.2 mmol) in acetic acid (70 ml) was treated with methyl-2,2,2-trichloroacetimidate (1.5 ml, 12.2 mmol) and the resulting solution left to stir at room temperature for 16 hours. The solvent was removed in vacuo and the residue was dissolved in methanol (100 ml) and heated to reflux for 4 hours. The solvent was removed in vacuo and the residue partitioned between saturated aqueous sodium bicarbonate (100 ml) and ethyl actetae (100 ml). The organic phase was separated, dried (sodium sulphate) and reduced in vacuo. Purification by flash column chromatography on silica gel eluting with pentane:ethyl acetate (90:10 changing to 50:50, by volume) gave the title compound as a yellow solid (963 mg).
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Reference:
Patent; Lane, Charlotte Alice Louise; Price, David Anthony; US2006/111416; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics