Related Products of 1996-29-8,Some common heterocyclic compound, 1996-29-8, name is 1-Bromo-4-chloro-2-fluorobenzene, molecular formula is C6H3BrClF, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Add Intermediate 18 (Int-18) (39.6 g, 134 mmol),1-bromo-4-chloro-2-fluorobenzene (28 g, 134 mmol), K2 CO3 (37 g, 267 mmol) and Pd (PPh3) 4 (4.6 g, 4 mmol) were dissolved in 180 ml of distilled water and 650 ml of THF in a round bottom flask, and then refluxed and stirred at 60 C for 12 hours.When the reaction is complete, the resultant is poured into an excess of methanol,And the obtained mixture was stirred at room temperature for 30 minutes.The solids were filtered, dried and processed by column chromatography (hexane: DCM (30%)).To obtain 26 g (65%) of Intermediate 19 (Int-19).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-4-chloro-2-fluorobenzene, its application will become more common.
Reference:
Patent; Samsung Sdi Co Ltd; Kim, Changwoo; Lee, Seungjae; Kim, Hyung Sun; Ryu, Dong Wan; Shin, Chang Ju; Jang, Kipo; Jung, Sung Hyun; Jung, Juyeon; Chu, Handong; (79 pag.)TW2019/30299; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics