Electric Literature of 932-32-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 932-32-1, name is 2-Chloro-N-methylaniline, This compound has unique chemical properties. The synthetic route is as follows.
Example 9-28; Compound 1 (80 mg) was suspended in methylene chloride (12 ml), and then thereto were added DMF (9 mul) and oxalyl chloride (94 mul), and the mixture was heated to reflux for an hour. The reaction solution was cooled, and then concentrated under reduced pressure. The residue was suspended in chloroform (18 ml), and then thereto was added Compound 2 (180 mul). The mixture was stirred at room temperature for 90 minutes. To the reaction mixture was added water, and the mixture was separated, and then the solvent of the organic layer was distilled away under reduced pressure. To the residue were added THF (5 ml), methanol (1 ml) and 1N-aqueous sodium hydroxide solution (550 mul), and the mixture was stirred at room temperature for an hour. The reaction mixture was diluted with ethyl acetate, and then washed with water and saturated saline, and dried over anhydrous sodium sulfate. The solvent was distilled away under reduced pressure, and the resulting residue was purified by silica gel column chromatography (eluent chloroform-ethyl acetate 50:50 to 0:100 gradient), and then the resulting solid was triturated by a mixed solvent of ethyl acetate-n-hexane to give Compound 3 (47 mg) as a colorless powder.MS (APCI) 343/345 [M+H]+
The chemical industry reduces the impact on the environment during synthesis 2-Chloro-N-methylaniline. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Yamaguchi, Tetsuo; Ushirogochi, Hideki; Hirai, Miki; Imanishi, Yasuhiro; US2012/16117; (2012); A1;,
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