Adding a certain compound to certain chemical reactions, such as: 93-50-5, name is 4-Chloro-2-methoxyaniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 93-50-5, category: chlorides-buliding-blocks
General procedure: Aniline (0.94 g,0.010 mol) was added dropwise, with stirring, to syrupy phosphoricacid (15 mL) at 0C. Finely ground sodiumnitrite (0.83 g,0.012 mol) was added with stirring over 15 min. This solutionwas allowed to stand at 0C for ca. 1 h after which time urea(ca. 100 mg) was added to destroy unreacted nitrite. After a further30min at 0C, a solution of freshly distilledmercaptoaceticacid (0.92 g, 0.010 mol) in water (250 mL) at 0C was addedswiftlywithvigorous stirring,maintainingapHof ca. 4. After ca.1 h of stirring at 0C, a dense pale buff precipitate had formed.The suspension was then filtered, washed with distilled waterand dried in a vacuum desiccator. A second crop of precipitatewas obtainedonkeeping the filtrate for severalhours at 0C. Thecombined dried crops were purified by dissolving in a minimumof dry diethyl ether and adding dry petroleum ether (bp. 40-60C) at 0C. After 1 h at 0C, fine, very pale buff needles wereformed; these were filtered and dried in vacuo to give 1a (1.51 g,77%).
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Reference:
Article; Buglass, Alan J.; Datta, Mrityunjoy; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 193; 4; (2018); p. 218 – 224;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics