Electric Literature of 19752-55-7,Some common heterocyclic compound, 19752-55-7, name is 1-Bromo-3,5-dichlorobenzene, molecular formula is C6H3BrCl2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Intermediate 1-2 (6.0 g, 0.018 mol) in intermediate 1-3 (3.3 g, 0.008 mol), Pd (pph3) 4 (1.0 g, 0.0009 mol), potassium carbonate (6.5 g, 0.036 mol) in THF 130 mL of insert was reacted with stirring for 4 hours at 65 °C. After the end of the reaction H2O: column purification after determination in MC (n-HEXANE: MC) to compound 1 to afford 9.3 g (71percent). Intermediate 1-2 (6.0 g, 0.018 mol) in 1-bromo-3 ,5-dichlorobenzene (1.8 g, 0.008 mol) into the Example 1-Preparation Example 4 in the same manner used in the synthesis
The synthetic route of 19752-55-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; P&H Tech; Hyeon, Seo Young; Chong, Song Wook; Kim, Dong Won; (52 pag.)KR2015/137265; (2015); A;,
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