Related Products of 108-70-3,Some common heterocyclic compound, 108-70-3, name is 1,3,5-Trichlorobenzene, molecular formula is C6H3Cl3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 1; [0099] 3,5-Dichlorophenyl-isopropylsulfide (2); EMI20.0[0100] Method A; [0101] To a solution of 4N sodium hydroxide (0.8 ml) was added isopropylmercaptan (0.33 ml). The mixture was stirred for 10 minutes at room temperature. 1,3,5-Trichlorobenzene(1) (1.8 g, 10 mmol) and tetra n-butylammoniumbromide (322 mg, 1 mmol) were added thereto. The reaction mixture was refluxed under vigorous stirring at 140[deg.] C. for 5.5 hours. The reaction mixture was poured into ice-water, extracted with ethylacetate, washed with water, dried over sodium sulphate, filtrated and concentrated under reduced pressure. The obtained residue was chromatographed twice on silica gel (SiO2 18 g, elution: n-hexane) to yield the objective (2) (566 mg). Yield 85%. [0102] IR(film) 1555, 1400, 1375, 1360, 1155 cm<-1>. [0103] <1>H-NMR (CDCl3, 200 MHz) [delta]: 1.32 (6H, d, J=6.4 Hz), 3.42 (1H, sept, J=6.4 Hz), 7.15-7.25 (3H, m).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,3,5-Trichlorobenzene, its application will become more common.
Reference:
Patent; Aoki, Tsutomu; Konoike, Toshiro; US2003/195363; (2003); A1;,
Chloride – Wikipedia,
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