In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 16799-05-6 as follows. Product Details of 16799-05-6
The reaction bottle by adding 0.5 millimoles of 2 – phenyl indole, 1.0 mmol 3 – chlorobenzene ethyl alkyne bromine, 3 mmol (6 equiv) potassium hydroxide, 5 muM % (0.025mmol) Pd (OAc)2, 15 muM % (0.075mmol) PCy3, 1.5 ml of N, N – dimethyl formamide, under nitrogen conditions, 130 C stirring for 18 hours, stop heating and stirring, cooled to the room temperature, distilled under reduced pressure to get the crude product, through the column chromatography separation and purification, to obtain the target product, the used column chromatography eluant is petroleum ether, yield 65%. This embodiment of the obtained product hydrogen spectrogram and carbon spectrogram as shown in Figure 11, Figure 12 is shown
According to the analysis of related databases, 16799-05-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; South China University of Technology; Wu Wanqing; An Yanni; Li Jianxiao; Jiang Huanfeng; (16 pag.)CN106866664; (2017); A;,
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