Related Products of 104-11-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 104-11-0, name is 1-(4-Chlorophenyl)-N-methylmethanamine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a stirred solution of 22 (0.60 g, 3.85 mmol) and K2CO3 (0.71 g, 5.14 mmol) in anhydrous acetonitrile (150 mL) under N2 at 0 C, was added crude 21(o) (0.58 g, 2.57 mmol) and the reaction heated and allowed to progress under reflux for 6 h. Acetonitrile was then removed under reduced pressure and the reaction mixture worked up with ethyl acetate (100 mL) and saturated aqueous Na2CO3 (3 × 50 mL), dried (MgSO4) and concentrated in vacuo. The crude product was purified by column chromatography using mixtures of ethyl acetate:hexane (5:95) to (20:80) as eluent to give12(o)a as a yellow oil (0.45 g, 58%); 1H NMR (CDCl3, 400 MHz) delta 7.39-7.26 (9H, m, ArH), 4.55 (2H, s, H-1), 3.58 (2H, s, H-8), 3.50 (2H, s, H-10), 2.13 (3H, s, H-9); 13C NMR (CDCl3, 75 MHz) delta 137.4 (Arqu), 137.1 (Arqu), 134.7 (Arqu), 132.7 (Arqu), 130.7 (ArC-H), 130.2 (C-12/16), 129.6 (ArC-H), 128.3 (C-13/15), 128.1 (ArC-H), 127.7 (ArC-H), 61.5 (C-10), 59.9 (C-8), 52.0 (C-1), 41.9 (C-9). HRMS (ES): Found 301.1211 (M + H)+: C16H18ClN4 (M + H)+ requires 301.1215.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(4-Chlorophenyl)-N-methylmethanamine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Zishiri, Vincent K.; Hunter, Roger; Smith, Peter J.; Taylor, Dale; Summers, Robert; Kirk, Kiaran; Martin, Rowena E.; Egan, Timothy J.; European Journal of Medicinal Chemistry; vol. 46; 5; (2011); p. 1729 – 1742;,
Chloride – Wikipedia,
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