Related Products of 7006-52-2,Some common heterocyclic compound, 7006-52-2, name is N-Methyl-3-chloroaniline, molecular formula is C7H8ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2 mmol of trifluoroethylamine hydrochloride, 1 mL of water, 34 uL of acetic acid, 1 mL of dichloroethane, and a rubber stopper were placed in the reaction tube, and fixed on a stirrer. take 42 mg of sodium nitrite in a 1.5 mL sample tube. Add 1 mL of water to the sample tube and shakeThe sample tube dissolves sodium nitrite.Dissolving the dissolved sodium nitrite solution into the reaction tube with a syringe,Stir for half an hour at room temperature. dissolve the iron porphyrin of formula 4 with 1 mL of dichloromethane (R1 = CF3, R2 = R3 = H)(The catalytic amount is 9/1000 of the molar amount of the secondary amine), and 0.24 mmol of 3-chloro-N-methylaniline was taken in the sample tube. After half an hour, the mixed solution in the sample tube was dropped into the reaction tube, stirred while stirring, and the temperature was raised to 80 °C for 12 hours. The reaction solution was cooled to room temperature and filtered to remove a portion.The impurities are concentrated and purified by column chromatography to obtain the target product. The column chromatography eluent is a mixed solvent of petroleum ether and acetone. The structure of 3-chloro-N-methyl-N-(2,2,2-trifluoroethyl)aniline is as follows: The compound was a pale yellow liquid with a yield of 72percent and its nuclear magnetic data was as follows:
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route N-Methyl-3-chloroaniline, its application will become more common.
Reference:
Patent; Yuanjiang Hualong Catalysis Technology Co., Ltd.; Liu Qiang; Xu Guiming; Guo Cancheng; (16 pag.)CN108997145; (2018); A;,
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