Adding a certain compound to certain chemical reactions, such as: 54788-38-4, name is 2-Chloro-4-methoxy-1-methylbenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 54788-38-4, HPLC of Formula: C8H9ClO
To 2-chloro-4-methoxytoluene (344 muL, 2.5 mmol, 1.0 eq.) in MeCN (1.5 mL) at 0C is added NBS (500 mg, 3.0 mmol, 1.2 eq.) in 2 portions (2nd half after 30 min stirring). The reaction mixture is allowed to stir at r.t. for 18h. The solvent is removed in vacuo, and the residue is dissolved in DCM and washed with brine, dried over anhydrous Na2SO4, filtered and concentrated in vacuo to afford the expected product as a mixture, which is used as such in the next step
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Patent; GALAPAGOS NV; LES LABORATOIRES SERVIER; LABEGUERE, Frederic, Gilbert; HENG, Rama; DE CEUNINCK, Frederic, Andre; ALVEY, Luke, Jonathan; AMANTINI, David; BREBION, Franck, Laurent; DEPREZ, Pierre, Marc, Marie, Joseph; GOSMINI, Romain, Luc, Marie; JARY, Helene; PEIXOTO, Christophe; POP-BOTEZ, Iuliana, Ecaterina; VARIN, Marie, Laurence, Claire; (180 pag.)WO2017/211666; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics