Reference of 883499-24-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 883499-24-9, name is 1-Bromo-2-chloro-3-fluorobenzene, This compound has unique chemical properties. The synthetic route is as follows.
5.3) 1-Benzylsulfanyl-3-bromo-2-chloro-benzene (intermediate 16): To stirred phenyl-methanethiol (14.8 g, 119,36 mmol) in 175 ml DMF was added Cs2CO3 (38.89 g, 119.36 mmol) under argon. After 10 min 1-bromo-2-chloro-3-fluoro- benzene (25 g, 119.36 mmol) in 25 ml DMF was added and stirring was continued overnight at RT and then 3 h at 800C. After cooling the mixture was diluted with ethyl acetate/water and washed subsequently with 1 N HCI and brine. The organic layer was dried with MgSO4, filtered and evaporated. Purification by chromatography on silica gel yielded 22 g (59 %) as an amorphous, colourless solid.
The chemical industry reduces the impact on the environment during synthesis 1-Bromo-2-chloro-3-fluorobenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; SANOFI-AVENTIS; WO2009/103440; (2009); A1;,
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