Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2106-02-7, name is 2-Chloro-4-fluoroaniline, A new synthetic method of this compound is introduced below., Formula: C6H5ClFN
Acetic anhydride (20 ml) and 2-chloro-4-fluoro-aniline (4.22 g, 29 mmol) were successively added in a 100 ml flask at 100 C for 1 h.After completion of the reaction, the reaction mixture was poured into water, and extracted with ethyl acetate three times, and the organic phase was combined.The organic phase is washed successively with saturated aqueous sodium hydrogencarbonate solution and saturated brine.The organic phase was dried over anhydrous sodium sulfate and concentrated. The title compound was obtained after column chromatography, 2.81 g, yield: 43.29%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Jinan University; Ding Ke; Lu Xiaoyun; Mo Cheng; Li Xueqiang; Ren Xiaomei; Zhang Zhang; Tu Zhengchao; Luo Jinfeng; Jie Fuli.bulusi.simeier; Ya Dang.feng.patesen; (30 pag.)CN108503593; (2018); A;,
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