COA of Formula: C7H4Cl2O2. In 2020 EUR J MED CHEM published article about CARRIER PROTEIN REDUCTASE; MYCOLIC ACID BIOSYNTHESIS; CRYSTAL-STRUCTURE; CONDENSING ENZYMES; ENOYL REDUCTASE; ACP REDUCTASE; INHA; TARGET; FAS; IDENTIFICATION in [Faion, Leo; Pintiala, Catalin; Bourbiaux, Kevin; Piveteau, Catherine; Herledan, Adrien; Biela, Alexandre; Leroux, Florence; Deprez, Benoit; Willand, Nicolas; Flipo, Marion] Univ Lille, Inst Pasteur Lille, Drugs & Mol Living Syst U1177, INSERM, F-59000 Lille, France; [Djaout, Kamel; Frita, Rosangela; Moune, Martin; Vandeputte, Alexandre; Baulard, Alain R.] Univ Lille, CIIL Ctr Infect & Immun Lille, Inst Pasteur Lille, CHU Lille,U1019,UMR 9017,CNRS,Inserm, F-59000 Lille, France; [Cantrelle, Francois-Xavier; Hanoulle, Xavier] Univ Lille, Inst Pasteur Lille, INSERM,CHU Lille, U1167,RID AGE Risk Factors & Mol Determinants Agi, F-59000 Lille, France; [Cantrelle, Francois-Xavier; Hanoulle, Xavier] CNRS, Integrat Struct Biol ERL9002, F-59000 Lille, France; [Kremer, Laurent; Blaise, Mickael] Univ Montpellier, Inst Rech Infectiol Montpellier IRIM, CNRS, UMR 9004, F-34293 Montpellier, France; [Kremer, Laurent] Inst Rech Infectiol Montpellier, INSERM, Montpellier, France; [Tanina, Abdalkarim; Wintjens, Rene] Univ Libre Bruxelles, Fac Pharm, Dept RD3, Unite Microbiol Chim Bioorgan & Macromol CP206 04, B-1050 Brussels, Belgium in 2020, Cited 58. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.
Mycobacterium tuberculosis (M.tb), the etiologic agent of tuberculosis, remains the leading cause of death from a single infectious agent worldwide. The emergence of drug-resistant M.tb strains stresses the need for drugs acting on new targets. Mycolic acids are very long chain fatty acids playing an essential role in the architecture and permeability of the mycobacterial cell wall. Their biosynthesis involves two fatty acid synthase (FAS) systems. Among the four enzymes (MabA, HadAB/BC, InhA and KasA/B) of the FAS-II cycle, MabA (FabG1) remains the only one for which specific inhibitors have not been reported yet. The development of a new LC-MS/MS based enzymatic assay allowed the screening of a 1280 fragment-library and led to the discovery of the first small molecules that inhibit MabA activity. A fragment from the anthranilic acid series was optimized into more potent inhibitors and their binding to MabA was confirmed by F-19 ligand-observed NMR experiments. (C) 2020 Elsevier Masson SAS. All rights reserved.
COA of Formula: C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Faion, L; Djaout, K; Frita, R; Pintiala, C; Cantrelle, FX; Moune, M; Vandeputte, A; Bourbiaux, K; Piveteau, C; Herledan, A; Biela, A; Leroux, F; Kremer, L; Blaise, M; Tanina, A; Wintjens, R; Hanoulle, X; Deprez, B; Willand, N; Baulard, AR; Flipo, M or concate me.
Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics