SDS of cas: 50-30-6. In 2019.0 BIOORGAN MED CHEM published article about ACUTE LUNG INJURY; RESPIRATORY-DISTRESS-SYNDROME; NF-KAPPA-B; PATHWAY ACTIVATION; LIPOPOLYSACCHARIDE; INFLAMMATION; CHALCONE; ACID; MD-2; RESPONSIVENESS in [Qiu, Yinda; Zhang, Dingfang; Zhang, Wenxin; Wang, Guangbao; Chen, Wenbin; Liang, Guang; Li, Xiaokun; Zhang, Yali; Liu, Zhiguo] Wenzhou Med Univ, Chem Biol Res Ctr, Sch Pharmaceut Sci, 1210 Univ Town, Wenzhou 325035, Zhejiang, Peoples R China; [Qiu, Yinda] Chonnam Natl Univ, Coll Pharm, 300 Yongbong Dong, Gwangju 500757, South Korea; [Xiao, Zhongxiang] Wenzhou Med Univ, Affiliated Yueqing Hosp, Dept Pharm, Wenzhou 325035, Zhejiang, Peoples R China; [Wang, Yanyan] Heilongjiang Univ Chinese Med, Coll Pharm, Haerbin 150040, Heilongjiang, Peoples R China in 2019.0, Cited 34.0. The Name is 2,6-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-30-6.
Myeloid differentiation protein 2 (MD2) is a co-receptor of toll-like receptor 4 (TLR4) responsible for the recognition of lipopolysaccharide (LPS) and mediates a series of TLR4-dependent inflammatory responses in inflammatory lung diseases including acute lung injury (ALI). Targeting MD2 thus may provide a therapeutic strategy against these lung diseases. In this study, we identified a novel compound 4k with the potent anti-inflammatory activity among 39 methyl gallate derivatives (MGDs). MGD 4k exhibited a high binding affinity to MD2, which in turn prevented the formation of the LPS/MD2/TLR4 complex. In addition, MGD 4k significantly reversed the upregulation of LPS-induced inflammatory mediators such as tumor necrosis factor-alpha, interleukin-6, intracellular adhesion molecule-1, vascular cell adhesion molecule-1, and monocyte chemoattractant protein-1 in vitro and in vivo. Mechanistically, MGD 4k performed anti-inflammatory function by inactivating JNK, ERK and p38 signaling pathways. Taken together, our study identified MGD 4k as a novel potential therapeutic agent for ALI through inhibiting MD2, inflammatory responses, and major inflammation-associated signaling pathways.
SDS of cas: 50-30-6. About 2,6-Dichlorobenzoic acid, If you have any questions, you can contact Qiu, YD; Xiao, ZX; Wang, YY; Zhang, DF; Zhang, WX; Wang, GB; Chen, WB; Liang, G; Li, XK; Zhang, YL; Liu, ZG or concate me.
Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics