Recommanded Product: 1-Chloro-2-methylbenzene. In 2019 ORG BIOMOL CHEM published article about AEROBIC OXIDATION; MOLECULAR-OXYGEN; AROMATIC-COMPOUNDS; METAL; ACID; HALOGENATION; EFFICIENT; ALKANES; COPPER; CHLORIDE in [Li, Zi-Hao; Li, Jian-Wei] Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China; [Fiser, Bela] Ferenc Rakoczi II Transcarpathian Hungarian Inst, UA-90200 Beregszasz, Transcarpathia, Ukraine; [Fiser, Bela] Univ Miskolc, Inst Chem, Computat Mol Design Res Grp, H-3515 Miskolc, Hungary; [Jiang, Biao-Lin; Xu, Bao-Hua; Zhang, Suo-Jiang] Chinese Acad Sci, Beijing Key Lab Ion Liquids Clean Proc, Key Lab Green Proc & Engn, State Key Lab Multiphase Complex Syst,Inst Proc E, Beijing 100190, Peoples R China; [Xu, Bao-Hua; Zhang, Suo-Jiang] Univ Chinese Acad Sci, Coll Chem & Chem Engn, Beijing 100049, Peoples R China; [Li, Zi-Hao] Inst Proc Engn, Beijing, Peoples R China in 2019, Cited 58. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8.
The direct chlorination of C-H bonds has received considerable attention in recent years. In this work, a metal-free protocol for hydrocarbon C-H bond chlorination with commercially available N-chlorosuccinimide (NCS) catalyzed by N-hydroxyphthalimide (NHPI) with 2,3-dicyano-5,6-dichlorobenzoquinone (DDQ) functioning as an external radical initiator is presented. Aliphatic and benzylic substituents and also heteroaromatic ones were found to be well tolerated. Both the experiments and theoretical analysis indicate that the reaction goes through a process wherein NHPI functions as a catalyst rather than as an initiator. On the other hand, the hydrogen abstraction of the C-H bond conducted by a PINO species rather than the highly reactive N-centered radicals rationalizes the high chemoselectivity of the monochlorination obtained by this protocol as the latter is reactive towards the C(sp(3))-H bonds of the monochlorides. The present results could hold promise for further development of a nitroxy-radical system for the highly selective functionalization of the aliphatic and benzylic hydrocarbon C-H.
Recommanded Product: 1-Chloro-2-methylbenzene. About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Li, ZH; Fiser, B; Jiang, BL; Li, JW; Xu, BH; Zhang, SJ or concate me.
Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
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