Electric Literature of 13918-92-8,Some common heterocyclic compound, 13918-92-8, name is 2,4-Difluorobenzene-1-sulfonyl chloride, molecular formula is C6H3ClF2O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A flask containing 10 mmol of 3,4-methylenedioxyphenethylamine in 80 mL of dichloromethane was placed in an ice bath, then 13 mmol of pyridine was added to provide an alkaline environment. While stirring, 2 mmol of 2,4-difluorobenzenesulfonyl chloride was slowly added dropwise. After lh, the ice bath was removed, and the reaction was continued at room temperature for 3 h to stop the reaction. The reaction solution was washed with water three times, washed once with saturated sodium chloride and dried over anhydrous sodium sulfate. The solvent is recovered by filtration and rotary distillation, and hexane is added to the remaining oily liquid to crystallize. After the crystals are completely crystallized, the product is recrystallized to give the product as a pale yellow solid, N-(2,4-difluorobenzenesulfonyl)-3,4-methyleneoxyphenylethylamine, yield 99%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,4-Difluorobenzene-1-sulfonyl chloride, its application will become more common.
Reference:
Patent; Hebei University of Science and Technology; Liu Shouxin; Zhang Xiaofang; Zhang Zhiwei; Yang Yihua; Yang Jianhua; (12 pag.)CN104045645; (2018); B;,
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