Synthetic Route of 14862-52-3,Some common heterocyclic compound, 14862-52-3, name is 3,5-Dibromochlorobenzene, molecular formula is C6H3Br2Cl, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Synthesis Example 4: Synthesis of Intermediate I-4 (0144) (0145) Intermediate I-3 (50 g, 98 mmol) was dissolved in THF (1 L) under a nitrogen environment, 1-bromo-3-iodobenzene (33 g, 117 mmol, Sigma Aldrich Co., Ltd.) and tetrakis(triphenylphosphine)palladium (1 g, 0.98 mmol) were added thereto, and the mixture was stirred. Potassium carbonate saturated in water (34 g, 245 mmol) was added thereto, and the obtained mixture was heated and refluxed at 80 C. for 12 hours. When the reaction was complete, water was added to the reaction solution, and the mixture was extracted with dichloromethane (DCM), filtered after removing moisture with anhydrous MgSO4, and concentrated under a reduced pressure. This obtained residue was separated and purified through column chromatography to obtain Intermediate I-4 (50 g and 95%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Dibromochlorobenzene, its application will become more common.
Reference:
Patent; SAMSUNG SDI CO., LTD.; JUNG, Ho-Kuk; OH, Jae-Jin; RYU, Dong-Wan; HAN, Su-Jin; KANG, Gi-Wook; KANG, Eui-Su; KIM, Youn-Hwan; KIM, Hun; PARK, Jae-Han; YANG, Yong-Tak; YU, Eun-Sun; LEE, Han-ILL; JEONG, Woo-Seok; (124 pag.)US2017/222158; (2017); A1;,
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