Brief introduction of 3-Chloro-2,4-difluoroaniline

Adding a certain compound to certain chemical reactions, such as: 2613-34-5, name is 3-Chloro-2,4-difluoroaniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2613-34-5, 2613-34-5

(1-6) N-(3-chloro-2,4-difluorophenyl)-7-methoxy-6-((3S)-pyrrolidin-3- yloxy)quinazolin-4-amine; 1.43 g of the compound obtained in (1-5), 1.91 g of (R)-(-)-N-Boc-3- pyrrolidinol and 1.96 g of triphenylphosphine were added to 20 mi of methylene chloride, and 2.01 m? of diisopropylazodicarboxylate was added thereto dropwise. The resulting mixture was stirred at room temperature for 1 hour and distilled under a reduced pressure, and the residue was briefly purified by column chromatography (ethylacetate : methylenechloride : methanol – 20 : 20 : 1). The partially purified residue was then dissolved in 60 mi of 2-propanol, 1.17 g of 3- chloro-2,4-difluoroaniline was thereto, and the mixture was stirred at 100 C for 3 hours. The resulting mixture was distilled under a reduced pressure to remove the solvent, and the residue was dissolved in 60 mi of methylenechloride. 60 mi of trifluoroacetic acid was added thereto and the mixture was stirred at room temperature for 1 hour. The resulting mixture was distilled under a reduced pressure to remove the solvent. Saturated sodium bicarbonate solution was added to the resulting residue to make it basic, followed by extraction with chloroform. The organic layer was dried over anhydrous sodium sulfate, filtered, and distilled under a reduced pressure. The resulting residue was subjected to column chromatography (chloroform : methanol = 1 : 2) to obtain the title compound (2 g, 73%).1H-NMR (300MHz, CDCl3) delta 8.68 (s, IH), 8.35 (m, IH), 7.29 (s, IH), 7.09 (s, IH), 7.08 (m, IH), 5.03 (bm, IH), 4.02 (s, 3H), 3.37 (m, IH), 3.27 (m, IH), 3.11 (m, IH), 3.00 (m, IH), 2.24 (m, IH), 2.12 (m, IH); MS (ESI+): m/z = 407.19 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloro-2,4-difluoroaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; HANMI PHARM. CO., LTD.; WO2008/150118; (2008); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics