Adding a certain compound to certain chemical reactions, such as: 2687-12-9, name is Cinnamyl chloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2687-12-9, Quality Control of Cinnamyl chloride
To a suspension of 500 mg (1.99 mmol) of Example 11 Part A compound in 10 mL of THF, at 0C under argon, was added dropwise 2.5 mL (3.98 mmol) of n-BuLi (1.6 M in hexanes). The resulting orange solution was stirred at 0C for 0.5 h at which time 305 muL (2.19 mmol) of cinnamyl chloride was added. The reaction was warmed to RT and allowed to stir for 1 h at which time it was diluted with 1:1 ethyl acetate/water (30 mL). The organics were dried (NaSO4) and evaporated to dryness. Purification by crystallization from hot methanol provided 350 mg (48%) of title compound as a white solid. mp 95-97C. TLC Silica gel (1:1 hexanes/ethyl acetate) Rf = 0.59. MS (CI-NH3, + ions) m/e 368 (M+H).
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Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; EP904262; (2004); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics