Application of 4090-55-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4090-55-5 as follows.
(Synthesis of phosphorus compound (1)); The flask accommodating the post-reaction solution containing intermediate 2 was filled with 121. 4 g (1.2 mol) of triethylamine, 1.85 g (0.015 mol) of 4-(dimethylamino) pyridine, and 420 g of 1, 2-dichloroethane. While the mixed solution was stirred, a mixed solution of 177.1 g (0.96 mol) of material 1 and 450 g of 1,2-dichloroethane was added thereto at 20C over 2 hours. After that, the substances were reacted at the same temperature (20C) for 8 hours. The obtained post-reaction solution was neutralized at room temperature using an aqueous solution of hydrochloric acid in an amount corresponding to the excess amount of triethylamine. The resultant solution was kept still so as to be separated into different layers. Then, the organic layer was neutralized using an aqueous solution of sodium hydrogen carbonate. The organic layer was then washed with water twice. The obtained organic layer was dried by anhydrous magnesium sulfate. Toluene was added to the filtrate, and recrystallization was performed. Thus, 171. 4 g of phosphorus compound (1) was obtained. Phosphorus compound (1) had a purity measured by GPC (gel permeation chromatography) of 100% by area. The yield was 54.4%.
According to the analysis of related databases, 4090-55-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; DAIHACHI CHEMICAL INDUSTRY CO., LTD.; EP1632497; (2006); A1;,
Chloride – Wikipedia,
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