Electric Literature of 553-82-2,Some common heterocyclic compound, 553-82-2, name is 2,4-Dichloro-1-methoxybenzene, molecular formula is C7H6Cl2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2,4-Dichloro-1-methoxybenzene (3.54 g, 20 mmol) was added to a sulfonyl chloride (23.3 g, 200 mmol), and then stirred at 0 C for 2 hr.After the reaction is completed, pour into crushed ice and filter.The collected solid was dissolved in ethyl acetate (100 mL) and dried over anhydrous sodium sulfate.Filtration and concentration gave Compound 19A (3.67 g, 67%)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,4-Dichloro-1-methoxybenzene, its application will become more common.
Reference:
Patent; Jiangsu Xiansheng Pharmaceutical Co., Ltd.; Chen Huanming; Liang Bo; Cao Wenjie; Zhang Guiping; Zhao Zhongqiang; Jiang Zhaojian; Zuo Gaolei; Xu Wanmei; Gong Hongju; Zhang Peng; Wang Jianghuai; Li Qingsong; Gao Chunhua; (79 pag.)CN104045552; (2019); B;,
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