Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19230-27-4, name is 1,3-Dibromo-2-chlorobenzene, A new synthetic method of this compound is introduced below., category: chlorides-buliding-blocks
1,3-Dibromo-2-Chloro-Benzene 1eq(45.5g), 2-Aminophenylboronic acid 2eq (46.6 g), Tetrakis (triphenylphosphine) palladium (0) (Pd (PPh3) 4), 1-dibromo-2-chloro-5 mol% (9.82 g) and K2CO3 2eq (47.0 g) were suspended in toluene (12 times of solid content, 550 ml) and distilled water (5 times the amount of K2CO3, 235 ml) and refluxed under nitrogen stream for 18 hours. After completion of the reaction, the reaction mixture was extracted with toluene and distilled water. The organic layer was dried over magnesium sulfate (MgSO4), filtered and the filtrate was concentrated under reduced pressure. The organic solution was removed, and the residue was subjected to silica gel column chromatography with hexane: dichloromethane = 7: 3 (v / v), and the resulting solid was recrystallized from dichloromethane and acetone to obtain an intermediate a-1 (37 g, Y = 74%).
The synthetic route of 19230-27-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Samsung SDI Co., Ltd; Jang Gi-po; Kim Jun-seok; Lee Seung-jae; Hong Jin-seok; Kim Chang-u; Jeong Seong-hyeon; Kim Yeong-gwon; Ryu Eun-seon; Jeong Ho-guk; (30 pag.)KR2017/111538; (2017); A;,
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