I found the field of Chemistry very interesting. Saw the article Catalytic enantioselective synthesis of beta-amino alcohols by nitrene insertion published in 2021. Recommanded Product: 2,4-Dichlorobenzoic acid, Reprint Addresses Meggers, E (corresponding author), Philipps Univ Marburg, Fachbereich Chem, Hans Meerwein Str 4, D-35043 Marburg, Germany.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid
Chiral beta-amino alcohols are important building blocks for the synthesis of drugs, natural products, chiral auxiliaries, chiral ligands and chiral organocatalysts. The catalytic asymmetric beta-amination of alcohols offers a direct strategy to access this class of molecules. Herein, we report a general intramolecular C(sp(3))-H nitrene insertion method for the synthesis of chiral oxazolidin-2-ones as precursors of chiral beta-amino alcohols. Specifically, the ring-closing C(sp(3))-H amination of N-benzoyloxycarbamates with 2 mol% of a chiral ruthenium catalyst provides cyclic carbamates in up to 99% yield and with up to 99% ee. The method is applicable to benzylic, allylic, and propargylic C-H bonds and can even be applied to completely non-activated C (sp(3))-H bonds, although with somewhat reduced yields and stereoselectivities. The obtained cyclic carbamates can subsequently be hydrolyzed to obtain chiral beta-amino alcohols. The method is very practical as the catalyst can be easily synthesized on a gram scale and can be recycled after the reaction for further use. The synthetic value of the new method is demonstrated with the asymmetric synthesis of a chiral oxazolidin-2-one as intermediate for the synthesis of the natural product aurantioclavine and chiral beta-amino alcohols that are intermediates for the synthesis of chiral amino acids, indane-derived chiral Box-ligands, and the natural products dihydrohamacanthin A and dragmacidin A.
Welcome to talk about 50-84-0, If you have any questions, you can contact Zhou, ZJ; Tan, YQ; Shen, X; Ivlev, S; Meggers, E or send Email.. Recommanded Product: 2,4-Dichlorobenzoic acid
Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics