Electric Literature of 2613-34-5,Some common heterocyclic compound, 2613-34-5, name is 3-Chloro-2,4-difluoroaniline, molecular formula is C6H4ClF2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: The 4-chloro-6, 7, 8-trimethoxyquinazoline (7) (0.4 mmol) and aromatic amines (0.4 mmol) inisopropyl alcohol (5 mL) were stirred at reflux temperature for about 4 to 24 h and disappearance of 4-chloro-6, 7, 8-trimethoxyquinazoline (7) was monitored by TLC using ethyl acetate and hexanes. TLC tracking to no raw material points (expansion agent: petroleum ether: ethyl acetate = 1:1, V/V), stop the reaction, after cooling, solid precipitated, filtrated, recrystallized and dried to give 6, 7, 8- trimethoxyl-4-anilinoquinazoline (Tg1-14).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Chloro-2,4-difluoroaniline, its application will become more common.
Reference:
Article; Liu, Fang; Huai, Ziyou; Xia, Guotai; Song, Liuping; Li, Sha; Xu, Yulan; Hong, Kangjun; Yao, Mingyue; Liu, Gang; Huang, Yinjiu; Bioorganic and Medicinal Chemistry Letters; vol. 28; 14; (2018); p. 2561 – 2565;,
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