Computed Properties of C17H14N2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Pentafluorophenyl substitution of natural di(indol-3-yl)methane strongly enhances growth inhibition and apoptosis induction in various cancer cell lines. Author is Ahmad, Aamir; Dandawate, Prasad; Schruefer, Sebastian; Padhye, Subhash; Sarkar, Fazlul H.; Schobert, Rainer; Biersack, Bernhard.
Di(indol-3-yl)methane (=3,3′-methanediyldi(1H-indole), DIM, (1)) is a known weakly antitumoral compound formed by digestion of indole-3-carbinol (=1H-indol-3-ylmethanol), an ingredient of various Brassica vegetables. Out of a series of nine fluoroaryl derivatives of 1, three pentafluorophenyl derivatives 2c, 2h, and 2i were identified that exhibited a two to five times greater anti-proliferative effect and an increased apoptosis induction when compared with 1 in the following carcinoma cell lines: BxPC-3 pancreas, LNCaP prostate, C4-2B prostate, PC3 prostate and the triple-neg. MDA-MB-231 breast carcinoma. Compound 2h was particularly efficacious against androgen-refractory C4-2B prostate cancer cells (IC50=6.4 μM) and 2i against androgen-responsive LNCaP cells (IC50=6.2 μM). In addition, 2c and 2h exhibited distinct activity in three cancer cell lines resistant to 1.
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