Min, Jaeki; Guo, Kexiao; Suryadevara, Praveen K.; Zhu, Fangyi; Holbrook, Gloria; Chen, Yizhe; Feau, Clementine; Young, Brandon M.; Lemoff, Andrew; Connelly, Michele C.; Kastan, Michael B.; Guy, R. Kiplin published an article about the compound: 4-Chloroquinazoline-6,7-diol( cas:1145671-36-8,SMILESS:OC1=CC2=C(Cl)N=CN=C2C=C1O ).Application of 1145671-36-8. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1145671-36-8) through the article.
We previously reported a novel inhibitor of the ataxia-telangiectasia mutated (ATM) kinase, which is a target for novel radiosensitizing drugs. While our initial lead, compound 4, was relatively potent and nontoxic, it exhibited poor stability to oxidative metabolism and relatively poor selectivity against other kinases. The current study focused on balancing potency and selectivity with metabolic stability through structural modification to the metabolized site on the quinazoline core. We performed extensive structure-activity and structure-property relationship studies on this quinazoline ATM kinase inhibitor in order to identify structural variants with enhanced selectivity and metabolic stability. We show that, while the C-7-methoxy group is essential for potency, replacing the C-6-methoxy group considerably improves metabolic stability without affecting potency. Promising analogs 20, 27g, and 27n were selected based on in vitro pharmacol. and evaluated in murine pharmacokinetic and tolerability studies. Compound 27g possessed significantly improve pharmacokinetics relative to that of 4. Compound 27g was also significantly more selective against other kinases than 4. Therefore, 27g is a good candidate for further development as a potential radiosensitizer.
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Reference:
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