The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Condensation reaction of amino alcohols with imides. IV. Condensation products of β-(cycloamino)ethanols with succinimide and with phthalimide-formation of β-(cycloamino)ethylamines》. Authors are Nakajima, Kazuo.The article about the compound:2-(3,4-Dihydroquinolin-1(2H)-yl)ethanaminecas:37481-18-8,SMILESS:NCCN1CCCC2=C1C=CC=C2).Application of 37481-18-8. Through the article, more information about this compound (cas:37481-18-8) is conveyed.
cf. CA 57, 8545h. Seven aminoalcs. (RNCH2CH2OH) (I), where RN = (CH2)4N (a), (CH2)5N (b), β-tetrahydroquinoline (c), morpholino (d), 4-ethylpiperazino (e), 4-butylpiperazino (f), and 4-phenylpiperazino (g). I and phthalimide heated at 200° while removing the H2O formed yielded RNCH2CH2N(CO)2C6H4-o (II) (RN, m.p., b10, m.p. of picrate, and decomposition point of Pt salt given): a, 109°, 220°, 218°, 212°; b, 90°, 206°, 215°, 215°; c, 137°, 273°, 144°, 204°; d, 135°, 216°, 232°, 146°; e, 115°, 227°, 245° (decomposition), 265°; f, 75°, 252°, 260° (decomposition), 271°; g, 158°, 279°, 218° (decomposition), 262°. Similarly, I and succinimide yielded RNCH2CH2N(COCH2)2 (III) (RN, m.p., b10, m.p. of picrate, and decomposition point of Pt salt given): a, 55°, 170°, 158°, 212°; b, -, 170°, 190°, 230°; c, 115°, 210°, 180°, -; d, 75°, 170°, 181°, 175°; e, -, 199°, 245°, 245°; f, 65°, 223°, 225°, 255°; g, 141°, 272°, 175°, 236°. II and III refluxed with 20% HCl 3-5 hrs., phthalic acid or succinic acid filtered off, and the filtrate concentrated yielded RNCH2CH2NH2.HCl (IV.HCl). Free RNCH2CH2NH2 (IV) was obtained by a long extraction of neutralized IV.HCl with ether. (RN, b10, b760, m.p. of picrate, and decomposition point of Pt salt given) a, 33°, 165-6°, 210° (decomposition), 207°; b, 50°, 185°, ∼200 (decomposition), 218°; c, 157°, 290°, -, -; d, 81°, 204°, 177° (decomposition), 237°; e, 88°, 223-4°, 230°, 270°; f, 120°, 255°, 116°, 252°; g, (m. 80°), 191°, 326°, -. 210-40°.
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Chloride – Wikipedia,
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