So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Takatori, Kichitaro; Hasegawa, Takaaki; Nakano, Sueharu; Kitamura, Jiro; Kato, Nobuo researched the compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione( cas:4144-22-3 ).Computed Properties of C8H11NO2.They published the article 《Antifungal activities of N-substituted maleimide derivatives》 about this compound( cas:4144-22-3 ) in Microbiology and Immunology. Keywords: maleimide derivative antifungal. We’ll tell you more about this compound (cas:4144-22-3).
Maleimide (I) N-substituted derivatives were synthesized by the method of Y. Kanaoka et al. (1967) and their antifungal activities determined by the plate dilution method against Candida albicans, Aspergillus niger, Penicillium citrinum, and Trichophyton mentagrophytes. The N-alkyl derivatives were ineffective against all fungi tested. However, the N-thiadiazolyl derivatives exhibited activity against T. mentagrophytes at low concentrations The antifungal action of the N-thiadiazolyl derivatives of maleimide appears to depend on both an imido bond and 1,3,4-thiadiazole.
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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics